Octacalcium phosphate: Innovative vehicle for the local biologically active substance delivery in bone regeneration
نویسندگان
چکیده
Disadvantages of conventional drug delivery systems (DDS), such as systemic circulation, interaction with physiochemical factors, reduced bioavailability, and insufficient concentration at bone defect site, have underlined the importance developing efficacious local systems. Octacalcium phosphate (OCP) is presumed to be precursor biologically formed apatite, owing its similarity hydroxyapatite (HAp) readiness convert it. Specific crystal structure OCP constructed compiled apatite layers water layers, which make possible incorporation various ions in structure, making it feasible alter overall effect has system. Next that intrinsic property, characteristics high solubility, biodegradability osteoconductivity made indispensable tailor a carrier material. In this review, we present main progress done on utilizing an innovative vehicle provide suggestions for research pathways advantages tissue engineering. (OCP), being many assets when compared other calcium phosphates. Owing highly pertinent used active substances or regeneration. However, orchestrating OCP, order achieve best outcome, still pioneering concept, all-encompassing data scarce. Although several articles been published matter, date there no systematic overview pointing out benefits can bring field delivery. Here offer comprehensive overview, starting from synthesis morphology, biological significance has.
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ژورنال
عنوان ژورنال: Acta Biomaterialia
سال: 2021
ISSN: ['1742-7061', '1878-7568']
DOI: https://doi.org/10.1016/j.actbio.2021.08.021